Ryan Bogdan

​Associate Professor of Psychological & Brain Sciences
PhD, Harvard University
MA, Santa Clara University
BS, Santa Clara University
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    • Washington University
    • CB 1125
    • One Brookings Drive
    • St. Louis, MO 63130-4899
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    ​Ryan Bogdan’s research examines how genomic variation and environmental experience contribute to individual differences in neural phenotypes, behavior, and psychopathology (e.g., depression, anxiety, substance use disorders).

    Bogdan is particularly interested in understanding how differences emerge in reward and threat processing, as well as stress responsiveness, and the role of these factors in the development of psychopathology (e.g., depression, anxiety, substance use disorders). Within this work, is a focus on how early life adversity and later stress exposure shape risk for mental and physical health outcomes through gene expression, stress hormone and inflammation signaling, as well as brain structure and function. He uses a variety of methods including molecular genetics, GWAS, fMRI, EEG/ERP, pharmacologic challenge, twin studies, behavioral assessment, endocrine and inflammation assays, and self-report in both healthy and clinical populations across the lifespan.

    Selected Publications

    Bogdan R, Baranger DAA, Agrawal A. (2018; in press). Polygenic risk scores in clinical psychology: Bridging genomic risk to individual differences. Annual Review of Clinical Psychology, 14.

    Michalski LJ, Demers CH, Baranger DAA, Barch DM, Harms MP, Burgess GC, Bogdan R. (in press). Perceived stress is associated with increased rostral middle frontal gyrus cortical thickness: A family-based and discordant sibling investigation. Genes, Brain and Behavior.

    Baranger DAA, Margolis S, Hariri AR, Bogdan R. (2017). An earlier time of scan is associated with greater threat-related amygdala reactivity. Social Cognitive and Affective Neuroscience, 12, 1272-1283.

    Bogdan R, Salmeron BJ, Carey CE, Agrawal A, Calhoun VD, Garavan H, Hariri AR, Heinz A, Hill MN, Holmes A, Kalin NH, Goldman D. (2017). Imaging genetics and genomics in psychiatry: A critical review of progress and potential. Biological Psychiatry, 82, 165-175.

    Carey CE, Knodt AR, Drabant Conley E, Hariri AR, Bogdan R. (2017). Elevated reward-related reactivity indirectly links polygenic childhood ADHD risk to later problematic alcohol use. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2, 180-187.

    Di Iorio CR, Carey CE, Michalski LJ, Corral-Frías NS, Conley ED, Hariri AR, Bogdan R. (2017). Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function. Psychoneuroendocrinology, 80, 170-178.

    Carey CE, Agrawal A, Bucholz KK, Hartz SM, Lynskey MT, Nelson EC, Bierut LJ, Bogdan R. (2016). Associations between polygenic risk for psychiatric disorders and substance involvement. Frontiers in Genetics, 7, 149.

    Demers CH, Drabant Conley E, Bogdan R, Hariri AR. (2016). Interactions between anandamide and corticotropin-releasing factor signaling modulate human amygdala function and risk for anxiety disorders: An imaging genetics strategy for modeling molecular interactions. Biological Psychiatry, 80, 356-362.

    Carey CE, Agrawal A, Zhang B, Conley ED, Degenhardt L, Heath AC, Li D, Lynskey MT, Martin NG, Montgomery GW, Wang T, Bierut LJ, Hariri AR, Nelson EC, Bogdan R. (2015). Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. Journal of Abnormal Psychology, 124, 860-877.